SWIFT detection of SPIO-labeled stem cells grafted in the myocardium
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چکیده
منابع مشابه
SWIFT detection of SPIO-labeled stem cells grafted in the myocardium.
We report initial results from studies using sweep imaging with Fourier transformation (SWIFT) to detect superparamagnetic iron oxide (SPIO) particle-labeled stem cells in the rat heart. In experiments performed on phantoms containing titanium balls or SPIO-labeled cells, frequency-shifted signals surrounding the paramagnetic objects produced a pileup artifact visualized by SWIFT. Total signal ...
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Introduction Stem cell tracking is being performed in NMR as an indirect measurement of effects caused by iron nanoparticles which suffers from ambiguity and strong background dependency of the observed signal changes. Recently a method for direct imaging of magnetic particles has been introduced [1]. We present a setup for spectroscopic detection of magnetic nanoparticles along with measuremen...
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Introduction Therapeutic cell treatments have been applied to a large number of pathological diseases. Tracking the engraftment of cells is key to planning and assessing cell therapies. Migration dynamics and tissue integration are commonly assessed by locating iron-oxide labeled cells with T2* weighted MRI. Interpretation of the resulting signal voids can be challenging in preclinical scanners...
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Mesenchymal stem cells (MSCs) have been shown to improve cardiac electrophysiology when administered in the setting of acute myocardial infarction. However, the electrophysiological phenotype of MSCs in situ is not clear. We hypothesize that MSCs delivered intramyocardially to cryoinjured myocardium can engraft, but will not actively generate, action potentials. Cryoinjury-induced scar was crea...
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Stem cell transplantation is a new therapy applied to produce cardiac regeneration through differentiation or increase of heart myocytes or neovascular proliferation in patients in the end stage of congestive heart failure secondary to dilated cardiomyopathy, but the results are still unknown.
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ژورنال
عنوان ژورنال: Magnetic Resonance in Medicine
سال: 2010
ISSN: 0740-3194
DOI: 10.1002/mrm.22378